![]() ![]() ![]() In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless of lithium exposure. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. ![]() The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis ![]()
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![]() ![]() These effects are now running with full 32-bit floating point precision (128-bits per pixel), which greatly improves the quality of rendering and the accuracy of colors as they move through the processing pipeline.Įffect plugins can now use the GPU for rendering as well, and have full access to the Windows graphics libraries Direct2D, DirectWrite, and Windows Imaging Component (WIC). In addition, (almost**) all adjustments and effects now use the GPU, resulting in much higher performance by leveraging Direct2D’s imaging and effects system with pixel shaders implemented using Sergio Pedri’s fantastic ComputeSharp.D2D1 library. This improves performance, and also helps battery life on laptops. ![]() More of the UI is now using using the GPU, including the Layers and History windows, the ruler, the image list at the top of the main windows, and the UI for the Curves and Levels adjustments. In v5.0, support for the GPU has been greatly expanded. In v4.1, GPU acceleration was added to a few effects (blurs, mostly). Paint.NET, since v4.0, has already been using hardware accelerated rendering for drawing the canvas to the screen. Support for more brush shapes and types, including custom brushes, will be making an appearance in a future update. The newly rewritten brush engine is supported by all of the brush tools: Paintbrush, Eraser, Clone Stamp, and Recolor. This also enables new styles of drawing, such as the following which was drawn with a spacing value of 200%: The default is 15% which does a great job, but sometimes you need finer control. There is a new spacing property in the toolbar. Path smoothing, sometimes called stabilization, is now implemented (enabled by default in the toolbar): Most devices support this, including the Surface Pen and various drawing tablets from Wacom, UGEE, and more. Support for the Windows “pointer” input system (aka “Windows Ink”) is required. 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